MARIA DEL CARMEN
MENDEZ FERNANDEZ
Catedrática de Universidad
Publicaciones en las que colabora con MARIA DEL CARMEN MENDEZ FERNANDEZ (22)
2013
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High level of antibiotic production in a double polyphosphate kinase and phosphate-binding protein mutant of streptomyces lividans
FEMS Microbiology Letters, Vol. 342, Núm. 2, pp. 123-129
2009
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Chapter 11 Sugar Biosynthesis and Modification
Methods in Enzymology, Vol. 458, Núm. A, pp. 277-308
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Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity
ChemBioChem, Vol. 10, Núm. 2, pp. 296-303
2008
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Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster
Microbiology, Vol. 154, Núm. 3, pp. 781-788
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Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering
Metabolic Engineering, Vol. 10, Núm. 5, pp. 281-292
2006
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Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses
Applied and Environmental Microbiology, Vol. 72, Núm. 10, pp. 6644-6652
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Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species
ChemBioChem, Vol. 7, Núm. 2, pp. 366-376
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Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: Characterization of two glycosyltransferase genes
Applied Microbiology and Biotechnology, Vol. 73, Núm. 1, pp. 122-131
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The aureolic acid family of antitumor compounds: Structure, mode of action, biosynthesis, and novel derivatives
Applied Microbiology and Biotechnology
2005
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Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins
Chemical Communications, pp. 1604-1606
2004
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Engineering biosynthetic pathways for deoxysugars: Branched-chain sugar pathways and derivatives from the antitumor tetracenomycin
Chemistry and Biology, Vol. 11, Núm. 12, pp. 1709-1718
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Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus
Chemistry and Biology, Vol. 11, Núm. 4, pp. 547-555
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Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891
ChemBioChem, Vol. 5, Núm. 9, pp. 1181-1187
2002
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Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891
Journal of Natural Products, Vol. 65, Núm. 5, pp. 779-782
2001
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The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties
Molecular and General Genetics, Vol. 264, Núm. 6, pp. 827-835
2000
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The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin
Angewandte Chemie - International Edition, Vol. 39, Núm. 4, pp. 796-799
1999
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Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus
Molecular and General Genetics, Vol. 261, Núm. 2, pp. 216-225
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The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster
Journal of Bacteriology, Vol. 181, Núm. 2, pp. 642-647
1998
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Novel hybrid tetracenomycins through combinatorial biosynthesis using a glycosyltransferase encoded by the elm genes in cosmid 16F4 and which shows a broad sugar substrate specificity
Journal of the American Chemical Society, Vol. 120, Núm. 41, pp. 10596-10601
1997
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Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin
Journal of Bacteriology, Vol. 179, Núm. 10, pp. 3354-3357