Publications by the researcher in collaboration with MARIA DEL CARMEN MENDEZ FERNANDEZ (22)

2013

  1. High level of antibiotic production in a double polyphosphate kinase and phosphate-binding protein mutant of streptomyces lividans

    FEMS Microbiology Letters, Vol. 342, Núm. 2, pp. 123-129

2009

  1. Chapter 11 Sugar Biosynthesis and Modification

    Methods in Enzymology, Vol. 458, Núm. A, pp. 277-308

  2. Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity

    ChemBioChem, Vol. 10, Núm. 2, pp. 296-303

2008

  1. Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

    Microbiology, Vol. 154, Núm. 3, pp. 781-788

  2. Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

    Metabolic Engineering, Vol. 10, Núm. 5, pp. 281-292

2006

  1. Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

    Applied and Environmental Microbiology, Vol. 72, Núm. 10, pp. 6644-6652

  2. Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species

    ChemBioChem, Vol. 7, Núm. 2, pp. 366-376

  3. Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: Characterization of two glycosyltransferase genes

    Applied Microbiology and Biotechnology, Vol. 73, Núm. 1, pp. 122-131

  4. The aureolic acid family of antitumor compounds: Structure, mode of action, biosynthesis, and novel derivatives

    Applied Microbiology and Biotechnology

2005

  1. Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

    Chemical Communications, pp. 1604-1606

2004

  1. Engineering biosynthetic pathways for deoxysugars: Branched-chain sugar pathways and derivatives from the antitumor tetracenomycin

    Chemistry and Biology, Vol. 11, Núm. 12, pp. 1709-1718

  2. Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus

    Chemistry and Biology, Vol. 11, Núm. 4, pp. 547-555

  3. Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891

    ChemBioChem, Vol. 5, Núm. 9, pp. 1181-1187

2002

  1. Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

    Journal of Natural Products, Vol. 65, Núm. 5, pp. 779-782

2001

  1. The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties

    Molecular and General Genetics, Vol. 264, Núm. 6, pp. 827-835

2000

  1. The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin

    Angewandte Chemie - International Edition, Vol. 39, Núm. 4, pp. 796-799

1999

  1. Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus

    Molecular and General Genetics, Vol. 261, Núm. 2, pp. 216-225

  2. The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster

    Journal of Bacteriology, Vol. 181, Núm. 2, pp. 642-647

1998

  1. Novel hybrid tetracenomycins through combinatorial biosynthesis using a glycosyltransferase encoded by the elm genes in cosmid 16F4 and which shows a broad sugar substrate specificity

    Journal of the American Chemical Society, Vol. 120, Núm. 41, pp. 10596-10601

1997

  1. Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin

    Journal of Bacteriology, Vol. 179, Núm. 10, pp. 3354-3357