Bioquímica y Biología Molecular
Departamento
Ignacio
Varela Egocheaga
Publicaciones en las que colabora con Ignacio Varela Egocheaga (16)
2024
2021
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Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLLrearranged B cell acute lymphoblastic leukemia
Journal of Clinical Investigation, Vol. 131, Núm. 13
2020
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The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells
Journal of Biological Chemistry, Vol. 295, Núm. 7, pp. 2001-2017
2011
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Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53
EMBO Journal, Vol. 30, Núm. 11, pp. 2219-2232
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Hutchinson-Gilford progeria: Splicing-directed therapy in a new mouse model of human accelerated aging
Science Translational Medicine, Vol. 3, Núm. 106
2010
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Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
Aging Cell, Vol. 9, Núm. 6, pp. 947-957
2008
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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
Nature Medicine, Vol. 14, Núm. 7, pp. 767-772
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Envejecimiento acelerado y supresion tumoral: conexiones moleculares y oportunidades terapeuticas derivadas del estudio de ratones deficientes en la metaloproteasa face1/zmpste24
Envejecimiento acelerado y supresion tumoral: conexiones moleculares y oportunidades terapeuticas derivadas del estudio de ratones deficientes en la metaloproteasa face1/zmpste24
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Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice
Journal of Anatomy, Vol. 213, Núm. 5, pp. 509-519
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Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
Journal of Cell Biology, Vol. 181, Núm. 1, pp. 27-35
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Premature aging in mice activates a systemic metabolic response involving autophagy induction
Human Molecular Genetics, Vol. 17, Núm. 14, pp. 2196-2211
2007
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Human progeroid syndromes, aging and cancer: New genetic and epigenetic insights into old questions
Cellular and Molecular Life Sciences, Vol. 64, Núm. 2, pp. 155-170
2005
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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Nature, Vol. 437, Núm. 7058, pp. 564-568
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From immature lamin to premature aging: Molecular pathways and therapeutic opportunities
Cell Cycle, Vol. 4, Núm. 12, pp. 1732-1735
2003
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AtFACE-2, a functional Prenylated Protein Protease from Arabidopsis thaliana Related to Mammalian Ras-converting Enzymes
Journal of Biological Chemistry, Vol. 278, Núm. 43, pp. 42091-42097
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Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans
Biochemical Journal, Vol. 370, Núm. 3, pp. 1047-1054