Biología Funcional
Departamento
University of Kentucky
Lexington, Estados UnidosPublicaciones en colaboración con investigadores/as de University of Kentucky (35)
2021
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, Vol. 17, Núm. 1, pp. 1-382
2017
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Activation and Loading of the Starter Unit during Thiocoraline Biosynthesis
Biochemistry, Vol. 56, Núm. 34, pp. 4457-4467
2016
2014
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Activation and silencing of secondary metabolites in Streptomyces albus and Streptomyces lividans after transformation with cosmids containing the thienamycin gene cluster from Streptomyces cattleya
Archives of Microbiology, Vol. 196, Núm. 5, pp. 345-355
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Adenylation and S -methylation of cysteine by the bifunctional enzyme TioN in thiocoraline biosynthesis
Journal of the American Chemical Society, Vol. 136, Núm. 49, pp. 17350-17354
2013
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Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity
Chemistry and Biology, Vol. 20, Núm. 8, pp. 1022-1032
2012
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A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis
Journal of Medicinal Chemistry, Vol. 55, Núm. 12, pp. 5813-5825
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Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: Mechanism for formation of the 2,2′-bipyridyl ring
Chemistry and Biology, Vol. 19, Núm. 3, pp. 399-413
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Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy, Vol. 8, Núm. 4, pp. 445-544
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Ketoolivosyl-tetracenomycin C: A new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT
Bioorganic and Medicinal Chemistry Letters, Vol. 22, Núm. 6, pp. 2247-2250
2011
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Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from streptomyces griseus
Biochemistry, Vol. 50, Núm. 8, pp. 1421-1428
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Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties
Applied and Environmental Microbiology, Vol. 77, Núm. 2, pp. 435-441
2009
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Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity
ChemBioChem, Vol. 10, Núm. 2, pp. 296-303
2008
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Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster
Microbiology, Vol. 154, Núm. 3, pp. 781-788
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Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis
ChemBioChem, Vol. 9, Núm. 14, pp. 2295-2304
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Glycosylated derivatives of steffimycin: Insights into the role of the sugar moieties for the biological activity
ChemBioChem, Vol. 9, Núm. 4, pp. 624-633
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In vitro and in vivo antitumor activity of novel aureolic acid analogues generated by metabolic engineering of the biosynthetic pathways in Streptomyces argillaceus and Streptomyces griseus subsp griseus
EJC SUPPLEMENTS
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Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity
Journal of Natural Products, Vol. 71, Núm. 2, pp. 199-207
2006
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Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses
Applied and Environmental Microbiology, Vol. 72, Núm. 10, pp. 6644-6652