Publicaciones en colaboración con investigadores/as de University of Kentucky (27)

2013

  1. Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity

    Chemistry and Biology, Vol. 20, Núm. 8, pp. 1022-1032

2012

  1. A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis

    Journal of Medicinal Chemistry, Vol. 55, Núm. 12, pp. 5813-5825

  2. Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: Mechanism for formation of the 2,2′-bipyridyl ring

    Chemistry and Biology, Vol. 19, Núm. 3, pp. 399-413

  3. Ketoolivosyl-tetracenomycin C: A new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT

    Bioorganic and Medicinal Chemistry Letters, Vol. 22, Núm. 6, pp. 2247-2250

2011

  1. Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from streptomyces griseus

    Biochemistry, Vol. 50, Núm. 8, pp. 1421-1428

  2. Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties

    Applied and Environmental Microbiology, Vol. 77, Núm. 2, pp. 435-441

2009

  1. Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity

    ChemBioChem, Vol. 10, Núm. 2, pp. 296-303

2008

  1. Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

    Microbiology, Vol. 154, Núm. 3, pp. 781-788

  2. Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis

    ChemBioChem, Vol. 9, Núm. 14, pp. 2295-2304

  3. Glycosylated derivatives of steffimycin: Insights into the role of the sugar moieties for the biological activity

    ChemBioChem, Vol. 9, Núm. 4, pp. 624-633

  4. Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

    Journal of Natural Products, Vol. 71, Núm. 2, pp. 199-207

2006

  1. Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

    Applied and Environmental Microbiology, Vol. 72, Núm. 10, pp. 6644-6652

  2. Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: New derivatives with antitumor activity

    Applied and Environmental Microbiology, Vol. 72, Núm. 1, pp. 167-177

  3. Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: Characterization of two glycosyltransferase genes

    Applied Microbiology and Biotechnology, Vol. 73, Núm. 1, pp. 122-131

  4. Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

    Applied and Environmental Microbiology, Vol. 72, Núm. 6, pp. 4172-4183

2005

  1. Combinatorial biosynthesis of antitumor indolocarbazole compounds

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Núm. 2, pp. 461-466

  2. Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

    Chemical Communications, pp. 1604-1606

  3. Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: Sugar donor substrate flexibility of the StaG glycosyltransferase

    Molecular Microbiology, Vol. 58, Núm. 1, pp. 17-27

  4. Elucidation of the glycosylation sequence of mithramycin biosynthesis: Isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII

    ChemBioChem, Vol. 6, Núm. 4, pp. 632-636

  5. Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone

    Journal of Organic Chemistry, Vol. 70, Núm. 2, pp. 631-638