Publicacions en col·laboració amb investigadors/es de Medical University of South Carolina (17)

2002

  1. Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces Argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway

    Journal of the American Chemical Society, Vol. 124, Núm. 8, pp. 1606-1614

  2. Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

    Journal of Natural Products, Vol. 65, Núm. 5, pp. 779-782

  3. Rationally designed glycosylated premithramycins: Hybrid aromatic polyketides using genes from three different biosynthetic pathways

    Journal of the American Chemical Society, Vol. 124, Núm. 21, pp. 6056-6062

  4. The Biosynthetic gene cluster for the antitumor rebeccamycin: Characterization and generation of indolocarbazole derivatives

    Chemistry and Biology, Vol. 9, Núm. 4, pp. 519-531

2001

  1. Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus: Characterization of three methyltransferase genes

    Journal of Biological Chemistry, Vol. 276, Núm. 22, pp. 18765-18774

  2. Identification of a sugar flexible glycosyltransferase from streptomyces olivaceus, the producer of the antitumor polyketide elloramycin

    Chemistry and Biology, Vol. 8, Núm. 3, pp. 253-263

  3. The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties

    Molecular and General Genetics, Vol. 264, Núm. 6, pp. 827-835

2000

  1. Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus

    Molecular and General Genetics, Vol. 262, Núm. 6, pp. 991-1000

  2. Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus

    Journal of Biological Chemistry, Vol. 275, Núm. 5, pp. 3065-3074

  3. Generation of hybrid elloramycin analogs by combinatorial biosynthesis using genes from anthracycline-type and macrolide biosynthetic pathways

    Journal of Molecular Microbiology and Biotechnology, Vol. 2, Núm. 3, pp. 271-276

  4. The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin

    Angewandte Chemie - International Edition, Vol. 39, Núm. 4, pp. 796-799

1999

  1. Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus

    Molecular and General Genetics, Vol. 261, Núm. 2, pp. 216-225

  2. Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

    Chemistry and Biology, Vol. 6, Núm. 1, pp. 19-30

  3. The biosynthesis of aureolic acid group antibiotics

    Bioorganic Chemistry, Vol. 27, Núm. 1, pp. 41-54

  4. The structure of mithramycin reinvestigated

    Journal of Natural Products, Vol. 62, Núm. 1, pp. 119-121

1998

  1. Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin

    Journal of Bacteriology, Vol. 180, Núm. 18, pp. 4929-4937

  2. Novel hybrid tetracenomycins through combinatorial biosynthesis using a glycosyltransferase encoded by the elm genes in cosmid 16F4 and which shows a broad sugar substrate specificity

    Journal of the American Chemical Society, Vol. 120, Núm. 41, pp. 10596-10601