JOSE MARIA
PEREZ FREIJE
Catedrático de Universidad
Instituto Universitario de Oncologia del Principado de Asturias
Oviedo, EspañaPublications in collaboration with researchers from Instituto Universitario de Oncologia del Principado de Asturias (53)
2024
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Assessing microbiota composition in the context of aging
Methods in Cell Biology (Academic Press Inc.), pp. 73-85
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Noncoding RNA Contribution to Aging and Lifespan
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 79, Núm. 4
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The hallmarks of aging as a conceptual framework for health and longevity research
Frontiers in Aging, Vol. 5
2023
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USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
Cell Death and Disease, Vol. 14, Núm. 1
2022
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Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells
EMBO Journal, Vol. 41, Núm. 21
2020
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Ubiquitin-specific proteases as targets for anticancer drug therapies
Cancer-Leading Proteases: Structures, Functions, and Inhibition (Elsevier), pp. 73-120
2019
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Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome
Nature Medicine, Vol. 25, Núm. 3, pp. 423-426
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Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
Nature Medicine
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Retraction Note: NF-κB activation impairs somatic cell reprogramming in ageing (Nature Cell Biology, (2015), 17, 8, (1004-1013), 10.1038/ncb3207)
Nature Cell Biology
2018
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Loss of the deubiquitinase usp36 destabilizes the rna helicase dhx33 and causes preimplantation lethality in mice
Journal of Biological Chemistry, Vol. 293, Núm. 6, pp. 2183-2194
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Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
Cell Reports, Vol. 24, Núm. 9, pp. 2392-2403
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Protease silencing to explore the molecular mechanisms of cancer and aging
Methods in Molecular Biology (Humana Press Inc.), pp. 261-269
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The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function
PLoS Biology, Vol. 16, Núm. 10
2017
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Deubiquitination in cancer stem cells
Aging
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Functional relevance of deubiquitinases in life and disease
Proteases in Physiology and Pathology (Springer Singapore), pp. 355-382
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USP39 deubiquitinase is essential for KRAS oncogene-driven cancer
Journal of Biological Chemistry, Vol. 292, Núm. 10, pp. 4164-4175
2016
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Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype
Journal of Clinical Investigation, Vol. 126, Núm. 10, pp. 3879-3893
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Metabolic Control of Longevity
Cell, Vol. 166, Núm. 4, pp. 802-821
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The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis
Oncotarget, Vol. 7, Núm. 46, pp. 74427-74434
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The novel tumor suppressor AIRAPL regulates IGF1R proteostasis
Cell Cycle