CARLOS
LOPEZ OTIN
Catedrático de Universidad
Hospital Universitario Central de Asturias
Oviedo, EspañaPublications en collaboration avec des chercheurs de Hospital Universitario Central de Asturias (40)
2019
-
Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia
Haematologica, Vol. 104, Núm. 3, pp. 576-586
2018
-
Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia
Leukemia, Vol. 32, Núm. 3, pp. 645-653
-
Loss of the deubiquitinase usp36 destabilizes the rna helicase dhx33 and causes preimplantation lethality in mice
Journal of Biological Chemistry, Vol. 293, Núm. 6, pp. 2183-2194
-
The mutational landscape of small lymphocytic lymphoma compared to non-early stage chronic lymphocytic leukemia
Leukemia and Lymphoma, Vol. 59, Núm. 10, pp. 2318-2326
2017
-
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes
Nature Genetics, Vol. 49, Núm. 5, pp. 730-741
-
Immune and inflammatory responses to DNA damage in cancer and aging
Mechanisms of Ageing and Development, Vol. 165, pp. 10-16
2016
-
Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling
Nature Medicine, Vol. 22, Núm. 1, pp. 91-96
-
MMP-25 metalloprotease regulates innate immune response through NF-κB signaling
Journal of Immunology, Vol. 197, Núm. 1, pp. 296-302
2015
-
Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
EMBO Journal, Vol. 34, Núm. 14, pp. 1875-1888
-
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Nature, Vol. 526, Núm. 7574, pp. 519-524
2014
-
ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity
Cell Reports, Vol. 8, Núm. 2, pp. 542-556
-
Exome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndrome
BMC Medical Genetics, Vol. 15, Núm. 1
-
Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome
Blood, Vol. 123, Núm. 24, pp. 3790-3796
-
Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy
Nature Communications, Vol. 5
2013
-
ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis
Autophagy, Vol. 9, Núm. 8, pp. 1188-1200
-
Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors
Cancer Research, Vol. 73, Núm. 1, pp. 395-405
-
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses
Journal of Biological Chemistry, Vol. 288, Núm. 20, pp. 14647-14656
-
NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome
Leukemia, Vol. 27, Núm. 5, pp. 1100-1106
2012
-
ADAMTS-12 metalloprotease is necessary for normal inflammatory response
Journal of Biological Chemistry, Vol. 287, Núm. 47, pp. 39554-39563
-
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice
EMBO Journal, Vol. 31, Núm. 9, pp. 2117-2133