FELIPE
LOMBO BRUGOS
Profesor Titular de Universidad
JOSE ANTONIO JULIO ADOLFO
SALAS FERNANDEZ
Investigador/a
Publicacions en què col·labora amb JOSE ANTONIO JULIO ADOLFO SALAS FERNANDEZ (23)
2013
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High level of antibiotic production in a double polyphosphate kinase and phosphate-binding protein mutant of streptomyces lividans
FEMS Microbiology Letters, Vol. 342, Núm. 2, pp. 123-129
2010
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A New Scaffold of an Old Protein Fold Ensures Binding to the Bisintercalator Thiocoraline
Journal of Molecular Biology, Vol. 397, Núm. 2, pp. 495-507
2009
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Chapter 11 Sugar Biosynthesis and Modification
Methods in Enzymology, Vol. 458, Núm. A, pp. 277-308
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Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity
ChemBioChem, Vol. 10, Núm. 2, pp. 296-303
2008
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Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster
Microbiology, Vol. 154, Núm. 3, pp. 781-788
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Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering
Metabolic Engineering, Vol. 10, Núm. 5, pp. 281-292
2006
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Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses
Applied and Environmental Microbiology, Vol. 72, Núm. 10, pp. 6644-6652
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Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species
ChemBioChem, Vol. 7, Núm. 2, pp. 366-376
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Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: Characterization of two glycosyltransferase genes
Applied Microbiology and Biotechnology, Vol. 73, Núm. 1, pp. 122-131
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The aureolic acid family of antitumor compounds: Structure, mode of action, biosynthesis, and novel derivatives
Applied Microbiology and Biotechnology
2005
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Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins
Chemical Communications, pp. 1604-1606
2004
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Engineering biosynthetic pathways for deoxysugars: Branched-chain sugar pathways and derivatives from the antitumor tetracenomycin
Chemistry and Biology, Vol. 11, Núm. 12, pp. 1709-1718
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Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus
Chemistry and Biology, Vol. 11, Núm. 4, pp. 547-555
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Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891
ChemBioChem, Vol. 5, Núm. 9, pp. 1181-1187
2002
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Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891
Journal of Natural Products, Vol. 65, Núm. 5, pp. 779-782
2001
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The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties
Molecular and General Genetics, Vol. 264, Núm. 6, pp. 827-835
2000
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The novel hybrid antitumor compound premithramycinone H provides indirect evidence for a tricyclic intermediate of the biosynthesis of the aureolic acid antibiotic mithramycin
Angewandte Chemie - International Edition, Vol. 39, Núm. 4, pp. 796-799
1999
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Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus
Molecular and General Genetics, Vol. 261, Núm. 2, pp. 216-225
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The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster
Journal of Bacteriology, Vol. 181, Núm. 2, pp. 642-647
1998
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Novel hybrid tetracenomycins through combinatorial biosynthesis using a glycosyltransferase encoded by the elm genes in cosmid 16F4 and which shows a broad sugar substrate specificity
Journal of the American Chemical Society, Vol. 120, Núm. 41, pp. 10596-10601