MARIO
FERNANDEZ FRAGA
Profesor Asociado
Instituto de Salud Carlos III
Madrid, EspañaPublicaciones en colaboración con investigadores/as de Instituto de Salud Carlos III (25)
2023
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A human genome editing–based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features
Blood, Vol. 142, Núm. 20, pp. 1752-1756
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The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma
Nature Communications, Vol. 14, Núm. 1
2022
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Blood DNA Methylation Patterns in Older Adults With Evolving Dementia
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 77, Núm. 9, pp. 1743-1749
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MATERNAL OBESITY AND GESTATIONAL DIABETES ARE ASSOCIATED WITH DNA METHYLATION ALTERATIONS IN THE OFFSPRING THROUGHOUT THE FIRST YEAR OF LIFE
Journal of hypertension, Vol. 40, pp. e53
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Pdx1 Is Transcriptionally Regulated by EGR-1 during Nitric Oxide-Induced Endoderm Differentiation of Mouse Embryonic Stem Cells
International Journal of Molecular Sciences, Vol. 23, Núm. 7
2021
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Conservation of Aging and Cancer Epigenetic Signatures across Human and Mouse
Molecular Biology and Evolution, Vol. 38, Núm. 8, pp. 3415-3435
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Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLLrearranged B cell acute lymphoblastic leukemia
Journal of Clinical Investigation, Vol. 131, Núm. 13
2019
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Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
Nucleic Acids Research, Vol. 47, Núm. 10, pp. 5016-5037
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Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes
Journal of Translational Medicine, Vol. 17, Núm. 1
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Natural history and cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL
Blood
2018
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Epigenome-wide analysis reveals specific DNA hypermethylation of T cells during human hematopoietic differentiation
Epigenomics, Vol. 10, Núm. 7, pp. 903-924
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Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma
Human Molecular Genetics, Vol. 27, Núm. 17, pp. 3046-3059
2017
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DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes
Nanotoxicology, Vol. 11, Núm. 7, pp. 857-870
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Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the “safe harbor” AAVS1 locus
Stem Cell Research, Vol. 21, pp. 137-140
2016
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Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
Journal of Translational Medicine, Vol. 14, Núm. 1
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Clinical and molecular analyses of Beckwith–Wiedemann syndrome: Comparison between spontaneous conception and assisted reproduction techniques
American Journal of Medical Genetics, Part A, Vol. 170, Núm. 10, pp. 2740-2749
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Differentiation of mouse embryonic stem cells toward functional pancreatic β-cell surrogates through epigenetic regulation of Pdx1 by nitric oxide
Cell Transplantation, Vol. 25, Núm. 10, pp. 1879-1892
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Longitudinal study of DNA methylation during the first 5 years of life
Journal of Translational Medicine, Vol. 14, Núm. 1
2015
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DNA methylation patterns in newborns exposed to tobacco in utero
Journal of Translational Medicine, Vol. 13, Núm. 1
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H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells
Genome Research, Vol. 25, Núm. 1, pp. 27-40