BIOSÍNTESIS DE COMPUESTOS BIOACTIVOS POR MICROORGANISMOS
BIOMIC
Instituto de Investigación Sanitaria del Principado de Asturias
Oviedo, EspañaPublicaciones en colaboración con investigadores/as de Instituto de Investigación Sanitaria del Principado de Asturias (23)
2024
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Antitumor Effect and Gut Microbiota Modulation by Quercetin, Luteolin, and Xanthohumol in a Rat Model for Colorectal Cancer Prevention
Nutrients, Vol. 16, Núm. 8
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Gut Microbiota and Inflammation Modulation in a Rat Model for Ulcerative Colitis after the Intraperitoneal Administration of Apigenin, Luteolin, and Xanthohumol
International Journal of Molecular Sciences, Vol. 25, Núm. 6
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Optimization of flavanonols heterologous biosynthesis in Streptomyces albidoflavus, and generation of auronols
Frontiers in Microbiology, Vol. 15
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Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller Streptomyces sp. CS113
International Journal of Molecular Sciences, Vol. 25, Núm. 4
2023
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Co-Expression of Transcriptional Regulators and Housekeeping Genes in Streptomyces spp.: A Strategy to Optimize Metabolite Production
Microorganisms, Vol. 11, Núm. 6
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Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034
Metabolites, Vol. 13, Núm. 10
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Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin
Microbial Cell Factories, Vol. 22, Núm. 1
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Metabolic engineering strategies for naringenin production enhancement in Streptomyces albidoflavus J1074
Microbial Cell Factories, Vol. 22, Núm. 1
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Optimized De Novo Eriodictyol Biosynthesis in Streptomyces albidoflavus Using an Expansion of the Golden Standard Toolkit for Its Use in Actinomycetes
International Journal of Molecular Sciences, Vol. 24, Núm. 10
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The Volatile Organic Compounds of Streptomyces spp.: An In-Depth Analysis of Their Antifungal Properties
Microorganisms, Vol. 11, Núm. 7
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Uncovering the Cryptic Gene Cluster ahb for 3-amino-4-hydroxybenzoate Derived Ahbamycins, by Searching SARP Regulator Encoding Genes in the Streptomyces argillaceus Genome
International Journal of Molecular Sciences, Vol. 24, Núm. 9
2022
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Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient β-Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family
ACS Chemical Biology, Vol. 17, Núm. 8, pp. 2320-2331
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Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase- Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147
Applied and Environmental Microbiology, Vol. 88, Núm. 1
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Combinatorial biosynthesis yields novel hybrid argimycin P alkaloids with diverse scaffolds in Streptomyces argillaceus
Microbial Biotechnology, Vol. 15, Núm. 12, pp. 2905-2916
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Identification of Antimicrobial Compounds in Two Streptomyces sp. Strains Isolated From Beehives
Frontiers in Microbiology, Vol. 13
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Volatile Compounds in Actinomycete Communities: A New Tool for Biosynthetic Gene Cluster Activation, Cooperative Growth Promotion, and Drug Discovery
Cells, Vol. 11, Núm. 21
2020
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Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family
ACS chemical biology, Vol. 15, Núm. 6, pp. 1541-1553
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Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin
Microbial Cell Factories, Vol. 19, Núm. 1
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New sipanmycin analogues generated by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway
Applied and Environmental Microbiology, Vol. 86, Núm. 3
2018
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Cooperative involvement of glycosyltransferases in the transfer of amino sugars during the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. strain CS149
Applied and Environmental Microbiology, Vol. 84, Núm. 18