FARMACOLOGÍA DEL DOLOR EXPERIMENTAL
FARMADEX
Universidad Miguel Hernández de Elche
Elche, EspañaUniversidad Miguel Hernández de Elche-ko ikertzaileekin lankidetzan egindako argitalpenak (18)
2023
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β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure–Activity Relationships and Antiallodynic Activity
International Journal of Molecular Sciences, Vol. 24, Núm. 19
2022
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β-Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models
International Journal of Molecular Sciences, Vol. 23, Núm. 5
2021
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A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability
Scientific Reports, Vol. 11, Núm. 1
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DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target
Bioorganic Chemistry, Vol. 115
2020
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Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their in Vitro Characterization and in Vivo Analgesic Activities
Journal of Medicinal Chemistry, Vol. 63, Núm. 17, pp. 9672-9694
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Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity
Scientific Reports, Vol. 10, Núm. 1
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Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies
ACS Chemical Neuroscience, Vol. 11, Núm. 3, pp. 268-290
2019
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1-(2′,5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity
ACS Chemical Neuroscience, Vol. 10, Núm. 8, pp. 3900-3909
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In vivo methods to study ThermoTRP channels in rodents
Methods in Molecular Biology (Humana Press Inc.), pp. 223-231
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Is TRPA1 burning down TRPV1 as druggable target for the treatment of chronic pain?
International Journal of Molecular Sciences, Vol. 20, Núm. 12
2018
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Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity
European Journal of Medicinal Chemistry, Vol. 143, pp. 157-165
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Identification of a Potent Tryptophan-Based TRPM8 Antagonist with in Vivo Analgesic Activity
Journal of Medicinal Chemistry, Vol. 61, Núm. 14, pp. 6140-6152
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Painful understanding of VEGF
Frontiers in Pharmacology, Vol. 9, Núm. NOV
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TRP channels as potential targets for sex-related differences in migraine pain
Frontiers in Molecular Biosciences, Vol. 5, Núm. AUG
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Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders
Journal of Medicinal Chemistry, Vol. 61, Núm. 10, pp. 4436-4455
2017
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Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis
Journal of Neuroinflammation, Vol. 14, Núm. 1
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Polyglycerol-opioid conjugate produces analgesia devoid of side effects
eLife, Vol. 6
2009
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Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Núm. 38, pp. 16451-16456