A multiomic atlas of the aging hippocampus reveals molecular rejuvenation in response to environmental stimulation (datasets and additional files)

  1. F. Pérez, Raúl 1
  2. Tezanos, Patricia 2
  3. Peñarroya, Alfonso 1
  4. González-Ramón, Alejandro 3
  5. G. Urdinguio, Rocío 1
  6. Gancedo-Verdejo, Javier 1
  7. Tejedor, Juan Ramón 1
  8. Santamarina-Ojeda, Pablo 1
  9. Alba-Linares, Juan José 1
  10. Sainz-Ledo, Lidia 1
  11. Roberti, Annalisa 1
  12. López, Virginia 1
  13. Mangas, Cristina 1
  14. Moro, María 2
  15. Cintado, Elisa 2
  16. Muela, Pablo 2
  17. Rodriguez-Santamaria, Mar 4
  18. Ortea, Ignacio 5
  19. Iglesias-Rey, Ramón
  20. Castilla-Silgado, Juan
  21. Tomás-Zapico, Cristina
  22. Iglesias-Gutiérrez, Eduardo
  23. Fernández-García, Benjamín
  24. Sanchez-Mut, Jose Vicente
  25. Trejo, Jose Luis
  26. F. Fernández, Agustín
  27. F. Fraga, Mario
  28. Montrer des auteurs +
  1. 1 Cancer Epigenetics and Nanomedicine Laboratory, Centro de Investigación en Nanomateriales y Nanotecnología-Consejo Superior de Investigaciones Científicas (CINN-CSIC), Universidad de Oviedo, 33011 Oviedo, Spain
  2. 2 Departamento de Neurociencia Translacional, Instituto Cajal-Consejo Superior de Investigaciones Científicas (IC-CSIC), 28002 Madrid, Spain
  3. 3 Laboratory of Functional Epi-Genomics of Aging and Alzheimer's disease, Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), 03550 Alicante, Spain
  4. 4 Bioterio y unidad de imagen preclínica, Universidad de Oviedo, 33006 Oviedo, Spain
  5. 5 Proteomics Unit, Centro de Investigación en Nanomateriales y Nanotecnología-Consejo Superior de Investigaciones Científicas (CINN-CSIC), Instituto de Investigación Sanitaria del Principado de Asturias (ISPA-FINBA), 33011 Oviedo, Spain
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Éditeur: Zenodo

Année de publication: 2024

Type: Dataset

DOI: 10.5281/ZENODO.8372431 lock_openAccès ouvert editor

Résumé

Aging is a universal biological phenomenon linked to many diseases, such as cancer or neurodegeneration. However, the molecular mechanisms underlying aging, or how lifestyle interventions such as cognitive stimulation can ameliorate this process, are yet to be clarified. Here, we performed a multi-omic profiling, including RNA-seq, ATAC-seq, ChIP-seq, EM-seq, SWATH-MS and single cell Multiome scRNA and scATAC-seq, in the dorsal hippocampus of young and old mouse subjects which were subject to cognitive stimulation using the paradigm of environmental enrichment. In this study we were able to describe the epigenomic landscape of aging and cognitive stimulation. This dataset contains information related to preprocessed datasets and additional files mentioned in the original manuscript.