The polymodal ion cahnnel trpc6 is present in meissner corpuscles co-expressed with trpv4
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R. Cabo
1
- P. López 1
- I. San José 2
- F. Pastor 2
- A. Gago 1
- G. Vázquez 1
- R. Cobo 1
- O. García-Suárez 1
- J.A. Vega 1
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1
Universidad de Oviedo
info
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2
Universidad de Valladolid
info
ISSN: 1136-4890, 2340-311X
Datum der Publikation: 2015
Ausgabe: 19
Nummer: S2
Seiten: 13
Kongress: XXVII CONGRESS OF THE SPANISH ANATOMICAL SOCIETY
Art: Konferenz-Beitrag
Zusammenfassung
The mechanoreceptors are the places where theprocess of transformation of the mechanical im-pulses into electric signal takes place. Consistentlysome types of mechanoreceptors, both in verte-brates and not vertebrates, express potentialmechanoproteins directly involved in the mecha-notransduction. Among putative mechanoproteinsare some ion channels belonging to TRP and Deg/ENa+C families. In this research we have investi-gated using double immunofluorescence the ex-pression of the mechanoproteins TRPC6 (transientreceptor potential canonical 6) and TRPV4(transient receptor potential vaniloid 4) in Meissnercorpuscles of human and Macaca fasciculata gla-brous digital skin. Both TRPC6 and TRPV4 arerelated to the mechanorecepcion, and co-expression of both has been associated to me-chanical algesia. The immunoreactivity for TRPC6and TRPV4 was co-localized with axonal markers,and never with specific markers for lamellar cells,in the axons of Meissner corpuscles, in both spe-cies. In addition, TRPV4 has also axonal localiza-tion, and co-localized with TRPC6. These resultsdemonstrate the presence and co-expression oftwo putative mechanoproteins in Meissner corpus-cles and probably this fact is at the basis of poly-modal role of Meissner corpuscles