Hypermethylation Of Hook2 Gene And Its Relation With Type 2 Diabetes Susceptibility In Individuals With Obesity

  1. Rodríguez-Rodero, Sandra 1
  2. Menéndez-Torre, Edelmiro 2
  3. Fernández-Bayón, Gustavo 3
  4. Morales-Sánchez, Paula 3
  5. Sanz, Lourdes 4
  6. Turienzo, Estrella 4
  7. González, Juan José 4
  8. Martinez-Faedo, Ceferino 5
  9. Suarez-Gutiérrez, Lorena 5
  10. Ares, Jessica 5
  11. Díaz-Naya, Lucia 5
  12. Martin-Nieto, Alicia 5
  13. Fernández-Morera, Juan L. 5
  14. Fraga, Mario F. 6
  15. Delgado-Álvarez, Elías 5
  1. 1 . Endocrinology and Nutrition Department. Hospital Universitario Central de Asturias (HUCA). Asturias. Spain
  2. 2 Endocrinology and Nutrition Department. Hospital Universitario Central de Asturias (HUCA). Asturias. Spain.
  3. 3 Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). HUCA. Universidad de Oviedo. Asturias. Spain.
  4. 4 Surgery Department. Hospital Universitario Central de Asturias. Asturias. Spain.
  5. 5 Endocrinology and Nutrition Department. Hospital Universitario Central de Asturias (HUCA). Asturias. Spain
  6. 6 Centro de Investigación en Nanomateriales y Nanotecnología (CINN). El Entrego. Asturias. Spain
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Verleger: Zenodo

Datum der Publikation: 2017

Art: Dataset

CC BY 4.0

DOI: 10.5281/ZENODO.841655 lock_openOpen Access editor

Zusammenfassung

Failure in glucose response to insulin is a common pathology associated with obesity. In this study, we analyzed the genome wide DNA methylation profile of visceral adipose tissue samples in a population of individuals with obesity and assessed whether differential methylation profiles are associated with the presence of type 2 diabetes (T2D). More than 485,000 CpG genome sites from visceral adipose tissue samples from women with obesity undergoing gastric bypass (n=18), and classified as suffering from type 2 diabetes or not (no type 2 diabetes, NT2D), were analyzed using DNA methylation arrays.