Polimorfismos serotoninérgicos y trastorno obsesivo-compulsivo

  1. P.A. Sáiz 1
  2. B. Morales 2
  3. M.P. García-Portilla 1
  4. M.T. Bascarán 1
  5. E. Coto 2
  6. V. Álvarez 2
  7. J.M. Fernández 1
  8. M. Bousoño 1
  9. J. Bobes 1
  1. 1 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

  2. 2 Hospital Central de Asturias
Journal:
Psiquiatría biológica: Publicación oficial de la Sociedad Española de Psiquiatría Biológica

ISSN: 1134-5934

Year of publication: 2001

Volume: 8

Issue: 6

Pages: 219-224

Type: Article

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More publications in: Psiquiatría biológica: Publicación oficial de la Sociedad Española de Psiquiatría Biológica

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Abstract

Objective: To investigate the possible association between four serotonin gene polymorphisms [T102C, A-1438G, 5-HTTLPR, VNTR5-HTT] and obsessive compulsive disorder (OCD). Patients and methods: We genotyped 41 OCD outpatients (DSM-IV criteria) (mean age: 36.22 [9.62], 31.7% males) and 119 healthy volunteers [blood donors] (mean age: 43.29 [11.28], 75.8% males) from Asturias. Polimorphisms were determined after PCR amplification followed by digestion with restriction enzymes and electrophoresis on an agarose gel. Results: 5-HT2A polymorphisms, both 5-HT2A polymorphisms (T102C and A-1438G) are in complete linkage desequilibrium in our population. T102C or A-1438G (OCD vs Controls): TT or AA: 22.0%, 19.3%; TC or AG: 48.8%, 52,9%; CC or GG: 29.3%, 27.7% (p = 0.908). Serotonin transporter polymorphisms¿ 5HTTLPR (OCD vs Controls): LL: 26.8%, 30.3%; LS: 56.1%, 47.9%; ss: 17.1%, 21.8% (p = 0.648). VNTR-5HTT (OCD vs Controls): 12rep12rep: 53.7%, 39.5%; 12rep10rep: 41.5%, 31.1%; 12rep9rep: 0%, 0.8%; 10rep10rep: 4.9%, 27.7%; 10rep9rep: 0%, 0,8% (p = 0.034). 12rep allele was more frequent in OCD patients; 74.4% vs 55.5%, p = 0.008. However, an analysis according gender shows that these differences only occur in women (p = 0.006 for genotype frequencies and p = 0.001 for allele frequencies). Conclusions: In women polymorphic variations in the VNTR in the serotonin transporter gene might influence susceptibility to OCD. However, larger samples are necessary to confirm or reject the current data.

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