Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces Argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway

  1. Remsing, L.L.
  2. Garcia-Bernardo, J.
  3. Gonzalez, A.
  4. Künzel, E.
  5. Rix, U.
  6. Braña, A.F.
  7. Bearden, D.W.
  8. Méndez, C.
  9. Salas, J.A.
  10. Rohr, J.
Revue:
Journal of the American Chemical Society

ISSN: 0002-7863

Année de publication: 2002

Volumen: 124

Número: 8

Pages: 1606-1614

Type: Article

DOI: 10.1021/JA0105156 GOOGLE SCHOLAR