Influence of environmental enrichment on the volume of brain regions sensitive to early life stress by maternal separation in rats

  1. Héctor González-Pardo 1
  2. Jorge Luis Arias Pérez 1
  3. Nélida María Conejo Jiménez 1
  1. 1 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

Revista:
Psicothema

ISSN: 0214-9915,  1886-144X

Año de publicación: 2019

Volumen: 31

Número: 1

Páginas: 46-52

Tipo: Artículo

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Otras publicaciones en: Psicothema

Resumen

Background: Exposure to maternal separation (MS) in rodents may have long-lasting consequences for the structure and function of several brain regions, eventually associated with alterations in cognition and emotion later in life. Post-weaning environmental enrichment (EE) has been reported to ameliorate the detrimental effects of exposure to early life stress mainly in the hippocampus. Method: In vivo magnetic resonance imaging (MRI) was applied to evaluate possible volumetric changes in the dorsal and ventral hippocampus, the medial prefrontal cortex and the dorsal striatum of 90-day-old male rats after daily MS for 240 min from postnatal days 2-21. Results: No signifi cant volume changes were found in the selected brain regions in MS animals as compared with an agematched control group. However, additional groups of control and MS animals with EE from days 21-60 showed signifi cant volume increases in the medial prefrontal cortex and the ventral hippocampus as compared to the groups without EE. In addition, general hemispheric asymmetry was found in the volume of the brain regions measured. Conclusions: Our results demonstrate that EE could have differential effects depending on previous exposure to MS and on the development of brain lateralization.

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