Epigenetics and its implications for Psychology

  1. González Pardo, Héctor 1
  2. Pérez Álvarez, Marino 1
  1. 1 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

Revista:
Psicothema

ISSN: 0214-9915

Año de publicación: 2013

Volumen: 25

Número: 1

Páginas: 3-12

Tipo: Artículo

Otras publicaciones en: Psicothema

Resumen

Background: Epigenetics is changing the widely accepted linear conception of genome function by explaining how environmental and psychological factors regulate the activity of our genome without involving changes in the DNA sequence. Research has identified epigenetic mechanisms mediating between environmental and psychological factors that contribute to normal and abnormal behavioral development. Method: the emerging field of epigenetics as related to psychology is reviewed. Results: the relationship between genes and behavior is reconsidered in terms of epigenetic mechanisms acting after birth and not only prenatally, as traditionally held. Behavioral epigenetics shows that our behavior could have long-term effects on the regulation of the genome function. In addition, epigenetic mechanisms would be related to psychopathology, as in the case of schizophrenia. In the latter case, it would be especially relevant to consider epigenetic factors such as life adversities (trauma, disorganized attachment, etc.) as related to its clinical manifestations, rather than genetic factors. Moreover, epigenetics implies overcoming classical dualist dichotomies such as nature-nurture, genotype-phenotype or pathogenesis-pathoplasty. Conclusions: In general, it can be stated that behavior and environment will finally take on a leading role in human development through epigenetic mechanisms

Referencias bibliográficas

  • Agranoff, B.W., Davis, R.E., & Brink, J.J. (1965). Memory fixation in the goldfish. PNAS, 54, 788-793.
  • Barahona, A., & Ayala, F. (2009). El siglo de los genes. Patrones de explicación en genética. Madrid: Alianza Editorial.
  • Berezikov, E., Cuppen, E., & Plasterk, R.H. (2006). Approaches to microRNA discovery. Nature Genetics, 38, Suppl.: S2-S7.
  • Bhaumik, S.R., Smith, E., & Shilatifard, A. (2007). Covalent modifications of histones during development and disease pathogenesis. Nature Structural & Molecular Biology, 14, 1008-1016.
  • Bird, A. (2007). Perceptions of epigenetics. Nature, 447, 396-398.
  • Bredy, T.W., Lin, Q., Wei, W., Baker-Andresen, D., & Mattick, J.S. (2011). MicroRNA regulation of neural plasticity and memory. Neurobiology of Learning & Memory, 96, 89-94.University Press.
  • Collins, F. (2011). El lenguaje de la vida. El DNA y la revolución de la medicina personalizada. Barcelona: Crítica.
  • Davis, H.P., & Squire, L.R. (1984). Protein synthesis and memory: A review. Psychological Bulletin, 96, 518-559.
  • Day, J.J., & Sweatt, J.D. (2010). DNA methylation and memory formation. Nature Neuroscience, 3, 1319-1323.
  • Dudley, K.J., Li, X., Kobor, M.S., Kippin, T.E., & Bredy, T.W. (2011). Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders. Neuroscience and Biobehavioral Reviews, 35, 1544-1551.
  • Dulac, C. (2010). Brain function and chromatin plasticity. Nature, 465, 728-735.
  • Falk, R. (1986). What is a gene? Studies in History and Philosophy of Science, 17, 133-173.
  • Fisher, H., & Craig, T. (2008). Childhood adversity and psychosis. In C. Morgan, K. McKenzie & P. Fearson (Eds.), Society and psychosis (pp.95-111). Cambridge, UK: Cambridge University Press.
  • Fraga, M.F, Ballester, E., Paz, M.F., Ropero, S., Setien, F., Ballestar, M.L.,... & Esteller, M. (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of National Academy of Science U S A, 26, 10604-10609.
  • Francis, R.C. (2011). Epigenetics. How environment shapes our genes. New York: Norton.
  • Gebicke-Haerter, P.J. (2012). Epigenetics and schizophrenia. Pharmacopsychiatry, 45, S42-S48.
  • Gerstein, M.B., Bruce, C., Rozowsky, J.S., Zheng, D., Du, J., Korbel, J.O., Emanuelsson, O., Zhang, Z.D., Weissman, S., & Snyder, M. (2007). What is a gene, post-ENCODE? History and updated definition. Genome Research, 17, 669-681.
  • Gottlied, G. (2000). Environmental and behavioral influences on gene activity. Current Directions in Psychological Science, 9, 93-97.
  • Griffiths, P.E., & Neumann-Held, E.M. (1999). The many faces of the gene. BioSciemce, 49, 656-662.
  • Gudsnuk, K.M., & Champagne, F.A. (2011). Epigenetic effects of early developmental experiences. Clinics in Perinatology, 38, 703-717.
  • Gupta, S., Kim, S.Y., Artis, S., Molfese, D.L, Schumacher, A., Paylor, R.E & Lubin, F.D. (2010). Histone methylation regulates memory formation. Journal of Neuroscience, 30, 3589-3599.
  • Hamilton, S.P. (2008). Schizophrenia candidate genes: Are we really coming up blank? American Journal of Psychiatry, 165, 420-423.
  • Harper, L.V. (2005). Epigenetic inheritance and the intergenerational transfer of experience. Psychological Bulletin, 131, 340-360.
  • Hochberg, Z., Feil, R., Constancia, M., Fraga, M., Junien, C., Carel, J.C., (2011). Child health, developmental plasticity, and epigenetic programming. Endocrine Reviews, 32, 159-224.
  • Holliday, R. (2002). Epigenetics comes of age in the twenty-first century. Journal of Genetics, 81, 1-4.
  • Jablonka, E., & Lamb, M.J. (2002). The changing concept of epigenetics. Annals of New York Academy of Sciences, 981, 82-96.
  • Jaroff, L. (1989). The gene hunt. Time, 133, 62-67.
  • Kay, L.E. (2000). Who wrote the book of life? Stanford, CA: Stanford University Press.
  • Keller, E.F. (2000). The Century of the Gene, Cambridge, MA and London: Harvard University Press.
  • Kendal, J., Tehrani, J.J., & Odling-Smee, J. (2011). Human niche construction in interdisciplinary focus. Philosophical Transactions of Royal Society Biological Sciences 366, 785-792.
  • Kitayama, S., & Uskul, A.K. (2010). Culture, mind, and the brain: Current evidence and future directions. Annual Review of Psychology, 62, 419-449.
  • Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I.,& Turecki, G. (2012). Genome-wide epigenetic regulation by early-life trauma. Archives of General Psychiatry, 69, 722-731.
  • Laland, K.N., Odling-Smee, J., & Myles, M. (2010). How culture shaped the human genome: Bringing genetics and the human sciences together. Nature Reviews Genetics, 11, 137-148.
  • Laland, K.N., Sterelny, K., Odding-Smee, J., Hoppitt, W., & Uller, T. (2011). Cause and effect in biology revisited: Is Mayr's proximate-ultimate dichotomy still useful?. type=journal>Science, 334, 1512-1516
  • Lashley, K.S. (1950). In search of the engram. Society of Experimental Biology Symposium No. 4: Physiological Mechanisms in Animal Behaviour (pp.2-31). Cambridge University Press.
  • Lesburguères, E., Gobbo, O.L, Alaux-Cantin, S., Hambucken, A., Trifilieff, P., & Bontempi, B. (2011). Early tagging of cortical networks is required for the formation of enduring associative memory. Science, 331, 924-928.
  • Lester, B.M., Tronick, E., Nestler, E., Abel, T., Kosofsky, B., Kuzawa, C.W., Marsit, C.J., Maze, I., Meaney, M.J., Monteggia, L.M., Reul, J.M., Skuse, D.H., Sweatt, J.D., & Wood, M.A. (2011). Behavioral epigenetics. Annals of the New York Academy of Sciences, 1226, 14-33.
  • Levenson, J. M., & Sweatt, J.D. (2005). Epigenetic mechanisms in memory formation. Nature Reviews Neuroscience, 6, 108-118.
  • Lewontin, R. (1974/2006). The analysis of variance and the analysis of causes. International Journal of Epidemiology, 35, 520-525.
  • Lewontin, R. (2001). El sueño del genoma humano y otras ilusiones. Barcelona: Paidós.
  • Li, S.-C. (2009). Brain in macro experiential context: Biocultural co- construction of lifespan neurocognitive development. Progress in Brain Research, 178, 17-29.
  • Liotti, L., & Gumley,A. (2008).An attachment perspective on schizophrenia: The role of disorganized attachment, dissociation and mentalization. InPsychosis, Trauma and Dissociation, A. Moskowitz, I. Schafer, M.J. Dorahy (Eds.). John Wiley & Sons, New York, pp. 117-133.
  • Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P.M., & Meaney, M.J. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science, 277, 1659-1662.
  • Masterpasqua, F. (2009). Psychology and epigenetics. Review of General Psychology, 13, 194-201.
  • McGowan, P.O., Sasaki A., D'Alessio A.C., Dymov S., Labonte, B., Szyf M., Turecki G., & Meaney M.J. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12, 342-348.
  • Meaney, M.J. (2001). Nature, nurture, and the disunity of knowledge. Annals of the New York Academy of Sciences, 935, 50-61.
  • Mill, J., Tang, T., Kaminsky, Z.A., Khare, T., Yazdanpanah, S., Bouchard, L. & Petronis, A. (2008). Epigenomic Profiling Reveals DNA Methylation Changes Associated with Major Psychosis. American Journal of Human Genetics, 82, 696-711.
  • Miller, C.A., Gavin, C.F., White, J.A., Parrish, R.R., Honasoge, A., Yancey, C.R, & Sweatt, J.D. (2010). Cortical DNAmethylation maintains remote memory. Nature Neuroscience, 13, 664-666.
  • Molfese, D.L. (2011). Advancing neuroscience through epigenetics:Molecular mechanisms of learning and memory. Developmental Neuropsychology, 36, 810-827.
  • Morgan, C., & Hutchinson, G. (2010). The sociodevelopmental origins of pschosis. In C. Morgan & D. Bhugra (Eds.), Principles of Social Psychiatry (pp. 193-214). Oxford: Wiley.
  • Moss, L. (2001). Deconstructing the gene and reconstructing molecular developmental systems. In S. Oyama, P.E. Griffiths & R.D. Gray (Eds.), Cycles of contingency. Developmental systems and evolution (pp.85-97). Cambridge, Mass: The MIT Press.
  • Murgatroyd, C., & Spengler, D. (2011). Epigenetic programming of the HPA axis: Early-life decides. Stress. DOI: 10.3109/10253890.2011.602146.
  • Neumann-Held, E.M. (2001). Let's talk about genes: The process molecular gene concept and its context. In S. Oyama, P.E. Griffiths & R.D. Gray (eds.) (2001), Cycles of contingency. Developmental systems and evolution (pp.69-84). Cambridge, Mass.: The MIT Press.
  • Newman S. A., & Bhat, R. (2008). Dynamical patterning modules: Physico-genetic determinants of morphological development and evolution. Physical Biology, 5, doi:10.1088/1478-3975/5/1/015008.
  • Newman, S.A. (2002). Developmental mechanisms: Putting genes in their place. Journal of Bioscience, 27, 97-104.
  • Newmann, S.A. (1988). Idealist biology. Perspectives in Biology and Medicine, 31, 353-368.
  • Nicolosi, G., & Ruivenkamp, G. (2012). The epigenetic turn. Some notes about the epistemological change of perspective in biosciences. Medicine, Health Care, and Philosophy, 15, 309-319.
  • Oyama, S., Griffiths, P.E., & Gray, R.D. (Eds.) (2001). Cycles of Contingency: Developmental Systems and Evolution. Cambridge, M.A.: MIT Press.
  • Pérez-Álvarez, M., & García-Montes, J.M. (2012). From neurochemistry to interpersonal chemistry: Towards a psychotherapy of schizophrenia. In A.J. Lancaster & O. Sharpe (Eds.), Psychotherapy: New Research. New York: Nova Science Publishers.
  • Pérez-Álvarez, M. (2012). Esquizofrenia y cultura moderna: razones de la locura. Psicothema, 24, 1-9.
  • Pigliucci, M. (2010). Phenotypic plasticity. In M. Pigliucci & G.B. Müller (Eds.), Evolution-The extended synthesis (pp. 355-378).Cambridge, Mass.: The MIT Press.
  • Portin, P. (2002). Historical development of the concept of the gene. Journal of Medicine and Philosophy, 68, 257-286.
  • Read, J., Bentall, R., & Rose, R. (2009). Time to abandon the bio-bio- bio model of psychosis: Exploring the epigenetic and psychosocial mechanisms by which adverse events lead to psychotic symptoms. Epidemiologia e Psichiatria Sociale, 18, 299-310.
  • Robert, J.S. (2004). Embriology, Epigenesis, and Evolution. Taking Development Seriously. Cambridge, UK: Cambridge University Press.
  • Robison, A.J., & Nestler, E.J. (2011). Transcriptional and epigenetic mechanisms of addiction. Nature Reviews Neuroscience, 12, 623-637.
  • Roth, T.L., Lubin, F.D., Sodhi, M., & Kleinman, J.E. (2009). Epigenetic mechanisms in schizophrenia. Biochimica et Biophysica Acta, 1790, 869-877.
  • Rutten, P.F., & Mill, J. (2009). Epigenetic mediation of environmental influences in major psychotic disorders. Schizophrenia Research, 35, 1045-1056.
  • Saetrom, P., Snøve, O. Jr., & Rossi, J.J. (2007). Epigenetics and microRNAs. Pediatric Research, 61(5 Pt 2): 7R-23R.
  • Sánchez, J.C., & Loredo, J.C. (2007). In circles we do. Baldwin's theory of organic selection and its current uses: A constructivist view. Theory and Psychology, 17, 33-58.
  • Stamatoyannopoulos, J.A. (2012). What does our genome encode? Genome Research, 22, 1602-1611.
  • Szyp, M., &Bick, J. (2012). DNA Methylation: A Mechanism for Embedding Early Life Experiences in the Genome. Child Development. DOI: 10.1111/j.1467-8624.2012.01793.x.
  • Toyokawa, S., Uddin, M., Koenen, K.C., & Galea, S. (2012). How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology. Social Science & Medicine, 74, 67-74.
  • Varese, F., Smeets, F., Drukker, M., Lieverse, R., Lataster, T., Viechtbauer, W., & Bentall, R.P. (2012). Childhood adversities increase the risk of psychosis: A meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophrenia Bulletin, 38, 661-671.
  • Venter, J.C., Adams, M.D., Myers, E.W., Li, P.W., Mural, R.J, Sutton, G.G., & Zhu, X. (2001). The sequence of the human genome. Science, 291, 1304-1351.
  • Vineis, P., & Pearce, N.E. (2011). Genome-wide association studies may be misinterpreted: genes versus heritability. Carcinogenesis, 32, 1295-1298.
  • Weaver, I.C., Cervoni, N., Champagne, F.A., D'Alessio, A.C., Sharma, S., Seckl, J.R., Dymov, S., Szyf, M., & Meaney, M.J. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7(8), 847-854.
  • Weigmann, K. (2004). The code, the text and the language of God. EMBO Reports, 5, 116-118.
  • Zhang, T.-Y., & Meaney, M.J. (2010). Epigenetics and the environmental regulation of the genome and its function. Annual Review of Psychology, 61, 439-466.