Effects of aromatase inhibition on spatial working memory and hippocampal astrocyte numbers

  1. Conejo Jiménez, Nélida María 1
  2. González Pardo, Héctor 1
  3. Arias, José Ignacio
  4. Arias Pérez, Jorge Luis 1
  1. 1 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

Revista:
Revista iberoamericana de psicología y salud

ISSN: 2171-2069

Año de publicación: 2012

Volumen: 3

Número: 1

Páginas: 1-18

Tipo: Artículo

DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Revista iberoamericana de psicología y salud

Resumen

Se sabe que las hormonas sexuales inducen la diferenciación sexual del cerebro durante el desarrollo temprano en mamíferos. La testosterona secretada por los machos ya durante la gestación está tradicionalmente asociada con la diferenciación sexual cerebral y conductual, gracias a su conversión a estradiol por el enzima aromatasa. Sin embargo, hay evidencia de que la inhibición de la aromatasa puede también deteriorar las funciones cognitivas en mujeres que reciben tratamiento hormonal para el cáncer de mama. Con el fin de estudiar los efectos de la aromatasa en el cerebro y la conducta, ratas prepúberes macho y hembra tratadas prenatalmente con anastrozol y durante el desarrollo temprano fueron evaluadas en una prueba de memoria de trabajo espacial. Los resultados muestran que el tratamiento con anastrozol deterioró claramente la memoria de trabajo en machos y hembras en comparación con grupos tratados con vehículo y control. Además, el número de astrocitos que expresaron la proteína glial fibrilar ácida (GFAP) disminuyó en el área CA3 del hipocampo dorsal sólo en ratas macho. Estos resultados indican que la aromatasa juega un papel complejo en la diferenciación sexual del cerebro y afecta a la memoria espacial en machos y hembras.

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